CISR operates four research laboratories - the Traffic and Networks Research Laboratory, the Driving Simulation Laboratory, Truck Driving Simulation Laboratory,and the Virtual Reality Laboratory. In addition, CISR utilizes the GW Virginia Campus Super-Computing Laboratory.

The Traffic and Networks Research Laboratory includes sensors, controllers, and software packages found in modern Advanced Traffic Management Centers. The laboratory is used to conduct research on fusion of sensors data, congestion management techniques, and new sensor technology.

The state-of-the-art Truck Driving Simulator Laboratory and Driving Simulator Laboratory are used to conduct vital vehicle and driving behavior research. The primary goal of this research is to avoid crashes and collisions on the road. These laboratories allows CISR to perform driving experiments in a safe and controlled laboratory setting. The driving simulators are used to conduct research with the primary goal of avoiding crashes and collisions on the road.

The Virtual Reality Laboratory focuses its research on transportation safety and security, emergency preparedness, and homeland defense applications. The laboratory enables interactive virtual environments; improved scenario definitions; advanced debugging, verification, and validation capabilities; and realistic 3-dimensional embedded environments for presentation, education, and training exercises.

In order to perform the extraordinarily complex calculations required for CISR's work, CISR operates a 32-processor SGI Origin 3200 supercomputer. Other systems available to researchers include a SGI Origin 2000, HP V-2200, Silicon Graphics Power Challenge XL, and Convex SPP-1600.